Glipizide is an oral blood glucose lowering drug in the sulphonylurea class. It acts by causing the beta cells in the pancreas to release insulin, and may also increase sensitivity to insulin.

A structural diagram of glipizide.
A structural diagram of glipizide.

Glipizide is used to treat type II diabetes in cats along with diet, exercise and insulin therapy if necessary. It is highly effective when combined with a low carbohydrate diet.

The most common side effects reported are vomiting, diarrhoea and hypoglycaemia.

Glipizide is safe and well-tolerated by most cats, and can avoid the use of insulin altogether. However, it should not be used in cats with liver or kidney disease, as this can result in pronounced hypoglycaemia.

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