Researchers at the RVC and the University of Kent have developed a cost-effective approach to mapping and assembling genomes using a novel method effective for bird species.

Chicken.
Researchers say mapping genomes will enable a “deeper understanding” of genetic characteristics.

Developed with funding from the Biotechnology and Biological Sciences Research Council, the method enables geneticists to assemble complete, chromosome-level genome assemblies.

Difficult and expensive

Genetics studies have long faced the problem that while sequencing an animal genome is easy and cheap, assembling sequences to complete chromosomes level is, in contrast, difficult and expensive.

Chromosome-level genome assembly, however, is deemed more useful to genetic science and practical application, but without significant investment, has been difficult to achieve for many species.

Also, traditional methods of chromosome-level genome assembly were time intensive and cost-inefficient in comparison to simple genome sequencing – therefore, as a result, most animal genomes sequenced are not assembled to chromosomes level.

Cost-effective and fast

The new method, developed by the RVC and University of Kent comparative genomics teams, and published in peer-reviewed journal Genome Research, allows geneticists to reach chromosome-level genome assembly cost-effectively and fast. The team’s breakthrough was to use universal probes to anchor scaffolds to chromosomes physically.

Until this study, the genomes of only three bird species had been published as assembled to complete chromosome level. Yet, using this method, the research team were able to map and assemble the complete genome of pigeons and the peregrine falcon, with all other bird species also easily accessible.

The method will have significant practical implications, says researchers; for example, in the farming industry, as mapping the genomes of bird species such as poultry, will enable a deeper understanding of genetic characteristics.

It will also enable diseases to be tackled at a genetic level.

 

View your activity >

Leave a Reply

Be the First to Comment!

Notify of
avatar

wpDiscuz

related content

Vets are being challenged to help researchers from the University of Liverpool as they attempt to establish the impact of fluke infection in horses across the UK.

4 mins

The RCVS has announced the winners of this year’s Queen’s Medal and Golden Jubilee Award – the highest honours the college can bestow on a veterinary surgeon and veterinary nurse.

4 mins

A leading veterinary dermatologist has called for vets to prescribe narrow-spectrum antibiotics for first-line cases of otitis externa to help reduce levels of multiple-resistant, chronic infections.

5 mins

A graduate programme to develop the next generation of vets is set to more than double its intake of recruits six months after launch.

4 mins

Anna Bruguera looks at bovine viral diarrhoea, its transmission, recognising clinical signs and UK eradication schemes in place.

34 mins

Andrew Kent looks at the aetiology, diagnosis, treatment options and monitoring of this common condition presenting in dogs

30 mins