An Irish veterinary biologics developer has announced positive results from a safety and efficacy study of a monoclonal antibody for the control of pain associated with osteoarthritis in dogs.

nexvet-logoNexvet Biopharma has completed the study of NV-01, the company’s anti-nerve growth factor monoclonal antibody therapy.

The primary endpoint achieved was a statistically significant (p=0.038) improvement over placebo in the assessed level of pain as measured using changes in client-specific outcome measures (CSOM) score between enrolment and day 28.

Additionally, NV-01 was found to be safe and well-tolerated, with no significant adverse safety signals observed in the study.

Positive results

Clinically meaningful magnitudes of benefit and statistically significant differences over placebo were also achieved for the majority of the secondary endpoints measured in the study. These included:

  • pain assessments measured using the validated pain scoring protocols CSOM
  • canine brief pain inventory at various points in time

Collectively, the results of this study constitute a substantial body of efficacy data that Nexvet intends to use as the basis of its planned submissions for marketing authorisations in both the US and Europe.

Nexvet chief executive Mark Heffernan said: “This is a tremendous outcome for Nexvet and we are particularly pleased to receive strong data supporting the long duration of efficacy following a single monthly injection – a key advantage for monoclonal antibody therapies over small molecules.

“This achievement is a testament to the power and potential of our proprietary PETization platform to produce effective 100% species-specific veterinary therapeutic candidates.”

View your activity >

Leave a Reply

Be the First to Comment!

Notify of
avatar

wpDiscuz

related content

Byre Vets in Werrington, Peterborough, Cambridgeshire is the latest to be added to a network of practices located in the nearby towns of Oundle, Thrapston, Corby and Stamford.

4 mins

Leeds-based Beechwood Veterinary Group is inviting pets to free nail clipping clinics to raise money for a local rescue fund that helps pay for the treatment and care of strays.

5 mins

The Veterinary Christian Fellowship is to explore pain management in companion animals via a CPD session at the University of Bristol's vet school in May.

1 mins

Vets and VNs can play their part in improving rabbit welfare in clinics by taking part in an online study from the University of Bristol.

3 mins

Coco – who suffered entropion since birth – has had her sight fully restored following eye surgery at The Mayhew Animal Home in London.

3 mins

To support National Microchipping Month in June, Virbac is providing a free support pack for practices to use in the waiting room and online – plus a chance for staff to win prizes.

2 mins