Alanine transferase (ALT) is a specific indicator of hepatocellular injury in dogs and cats. Increases occur due to cell damage and induction.

ALT is virtually liver specific in dogs and cats. Causes include:

  • Artefact – haemolysis
  • Drugs – anticonvulsants, steroids, any drugs causing hepatotoxicity
  • Disease – liver: both primary and secondary hepatic disease can increase ALT if altered cell membrane permeability or necrosis occur. Bile duct obstruction will increase ALT.
  • Trauma
  • Severe muscle injury
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