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Tyzzer’s disease is caused by Clostridium piliforme and can cause severe disease in many animal species.

Transmission is mainly through the fecal-oral route.

It is mostly seen in mice, but infected mice often do not exhibit clinical symptoms. Mice become carriers of the disease and spread the pathogen to other mice and other animal species.

Different mouse strains differ in their susceptibility to the pathogen.

Tyzzer’s disease can occasionally infect rats and should be considered as a possible cause in cases of diarrhoea and sudden death in this species.

The prognosis for affected individuals is very poor. Infection causes necrotic lesions in the liver, digestive organs and heart.

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