UK vets now have access to a novel antibiotic molecule to help combat bovine respiratory disease (BRD) in cattle, thanks to the launch of a new 16-membered, tribasic macrolide unique to animal health.

UK vets now have access to a novel antibiotic molecule to help combat bovine respiratory disease (BRD) in cattle, thanks to the launch of a new 16-membered, tribasic macrolide unique to animal health.

Zuprevo Cattle from MSD Animal Health contains the active ingredient tildipirosin (180mg/ml) and is licensed for the treatment and prevention of BRD associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni.

Zuprevo pack shotAccording to MSD Animal Health livestock veterinary adviser Paul Williams, the new product works extremely quickly in the animal, reaching peak plasma concentrations within 23 minutes of injection.

It also offers the longest duration of activity in the lungs of all the macrolide antibiotics currently on the market, maintaining lung concentration above the MIC90 for up to 28 days, he claimed.

Mr Williams explained that it was Zuprevo’s unique macrolide structure that allowed it to deliver these significant pharmacological benefits for the management of BRD in cattle.

“Zuprevo works by diffusing into the bacterial cell where its binding action inhibits protein synthesis of the bacterial ribosome,” he said. “Its unique 16-membered, tribasic structure enables enhanced penetration of the bacterial cell wall, as well as having the ability to bypass some potential bacterial resistance mechanisms.”

In addition to its important pharmacological benefits, Mr Williams says Zuprevo also offers vets and their farmer clients important practical usage advantages.

“Zuprevo is an easily syringeable solution for injection available in convenient 20ml, 50ml and 100ml vial sizes to suit different usage requirements. At a dose rate of 1ml/45kg, it offers the lowest macrolide dose volume per kg of bodyweight. At 47 days, Zuprevo also has the shortest macrolide meat withdrawal period,” he said.

 

  • Further information on this new macrolide antibiotic is available from the MSD Animal Health territory managers or by calling the company’s Veterinary Services Group on 01908 685685.
View your activity >

Leave a Reply

Be the First to Comment!

Notify of
avatar

wpDiscuz