Exploiting the genetic similarities between two strains of Streptococcus bacteria could lead to novel vaccines for both man and horse, according to a review published in the Journal of Medical Microbiology.
Two strains of Streptococcus bacteria, that have evolved to cause potentially fatal infections in either horses or humans, use the same box of tricks to cause disease. Exploiting their genetic similarities could lead to novel vaccines for both man and beast, according to a review published in the Journal of Medical Microbiology.
Streptococcus pyogenes is responsible for tonsillitis, scarlet fever and toxic shock syndrome in humans. Its equine equivalent, Streptococcus equi, infects horses to cause strangles. Each strain is well-adapted to their particular host yet their strategies for causing disease are remarkably similar.
Strangles is one of the most frequently diagnosed infectious diseases of horses worldwide. There are estimated to be more than 600 outbreaks in the UK each year, each costing up to many thousands of pounds to resolve.
The secret to the success of S.equi is its ability to trade genes with similar bacteria such as S.pyogenes, explained Andrew Waller from the Animal Health Trust, who conducted the review focusing on S.equi.
“These strains share clever tricks, like secreting ‘superantigens’ that allow the microbes to send the immune system into turmoil yet avoid detection themselves,” he said.
Another shared trait is the production of SlaA – a toxin related to the venom of the Australian brown snake – that is associated with serious disease in humans. “The resemblances between the two strains prove it is unrealistic to study human and animal pathogens in isolation, in our quest to understand and fight them,” stressed Dr Waller.
He explained: “Tracking the genetic evolution of micro-organisms such as S.equi will give us clues as to how its human counterpart S.pyogenes has evolved in the past and may evolve in the future. This will help equip us with the tools to combat the diseases caused by both pathogens.”
The emerging genetic data of S.equi is being used as a blueprint to develop a new vaccine against strangles, which ultimately could benefit both horses and humans.
Dr Waller said: “One vaccine against strangles that is currently being trialed uses antigenic components that share similarity with their S.pyogenes counterparts to stimulate immunity. If this approach can protect horses against S.equi, it is feasible that a similar cocktail of S.pyogenes antigens may be the basis for an effective vaccine for humans, which is an exciting prospect.”
- The Journal of Medical Microbiology is available online.